Systematic Review for the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular disease (ASCVD) events. Since publication of these guidelines, multiple randomized controlled trials evaluating nonstatin lipid-modifying medications have been published.
J Am Coll Cardiol. 2018 Nov 3. pii: S0735-1097(18)39035-1. doi: 10.1016/j.jacc.2018.11.004. [Epub ahead of print]
Wilson PWF, Polonsky TS, Miedema MD, Khera A, Kosinski AS, Kuvin JT.